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Trials, drawn as people

The same numbers the landmark trials reported, drawn as people instead of percentages. Each figure links to its source, and every rescaling is stated under the graphic.

DiRECT
Type 2 diabetes remission with an intensive weight-management program

Adults diagnosed with type 2 diabetes within the last 6 years, not on insulin (UK primary care)

Diabetes remission at 12 months (per 100 people at 12 months)
Usual best-practice care4 / 100
Reported: 6 of 149 (4%)
Weight-management program46 / 100
Reported: 68 of 149 (46%)
Diabetes remission was achieved in 68 (46%) participants in the intervention group and six (4%) participants in the control group (odds ratio 19·7, 95% CI 7·8-49·8; p<0·0001).
Lean ME, et al. Lancet. 2018;391(10120):541-551. (DiRECT)Source

Icons show the trial's reported percentages as people out of 100. At 24 months remission was 36% vs 3%.

At 24 months: 53 (36%) intervention vs 5 (3%) control participants remained in remission (Lancet Diabetes Endocrinol. 2019).

SSaSS
Stroke with a potassium-enriched salt substitute

Adults with a history of stroke or age 60+ with high blood pressure (600 villages, China)

Strokes per 1000 person-years (per 1000 person-years)
Regular salt34 / 1000
Reported: 33.65 events per 1000 person-years
Salt substitute (75% NaCl / 25% KCl)29 / 1000
Reported: 29.14 events per 1000 person-years
The rate of stroke was lower with the salt substitute than with regular salt (29.14 events vs. 33.65 events per 1000 person-years; rate ratio, 0.86; 95% confidence interval [CI], 0.77 to 0.96; P = 0.006).
Neal B, et al. N Engl J Med. 2021;385(12):1067-1077. (SSaSS)Source

Icons round the reported rates to whole people per 1000 person-years (29.14 shown as 29; 33.65 shown as 34).

Major cardiovascular events: 49.09 vs 56.29 per 1000 person-years. Death: 39.28 vs 44.61 per 1000 person-years. Both lower with the salt substitute.

PREDIMED
Major cardiovascular events with a Mediterranean diet

Adults at high cardiovascular risk without CVD at enrollment (Spain, median follow-up 4.8 years)

Major cardiovascular events over the trial (per 1000 people over ~4.8 years)
Control diet (advice to reduce fat)44 / 1000
Reported: 4.4% of participants
Mediterranean diet + extra-virgin olive oil38 / 1000
Reported: 3.8% of participants
...the hazard ratio was 0.69 (95% confidence interval [CI], 0.53 to 0.91) for a Mediterranean diet with extra-virgin olive oil and 0.72 (95% CI, 0.54 to 0.95) for a Mediterranean diet with nuts, as compared with the control diet.
Estruch R, et al. N Engl J Med. 2018;378(25):e34. (PREDIMED)Source

Icons show the reported crude event percentages (3.8% and 4.4%) as people out of 1000. The Mediterranean diet with nuts arm: 3.4%.

These are trial-level results in their own populations and time frames, shown exactly as reported. They are not a prediction for an individual patient, and different trials are not directly comparable to each other.

Project these effects across a panel or read the studies.